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Rockland
RCAN2 Polyclonal Antibody
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FIGURE: 1 / 3
RCAN2 Antibody (600-401-DX3) in ICC/IF
Immunofluorescence Microscopy of RCAN2 antibody. Tissue: Mouse brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: RCAN2 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: RCAN2 is cytoplasmic. Staining: RCAN2 as red fluorescent signal.
Product Details
600-401-DX3
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-RCAN2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the internal region of human RCAN2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcineurin inhibitory protein ZAKI-4; Calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene1-like 1; MCIP2; myocyte-enriched calcineurin interactin protein 2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4
Gene Aliases: CSP2; Dcip2; DSCR1L1; MCIP2; RCAN2; RCN2; ZAKI-4; ZAKI4
UniProt ID: (Human) Q14206, (Mouse) Q9JHG2, (Rat) Q8CH27
Entrez Gene ID: (Human) 10231, (Mouse) 53901, (Rat) 140666
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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