Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 2
Sequence of this protein is as follows: MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE DIHTSRVVAH VLPCGHLLHR GYRCPLCMHS ALDMTRYWRQ LDDEVAQTPM PSEYQNMTVD ILCNDCNGRS TVQFHILGMK CKICESYNTA QAGGRRISLD QQ
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Androgen receptor N-terminal-interacting protein; androgen-receptor N-terminal-interacting protein; CH-rich interacting match with PLAG1; CH-rich-interacting match with PLAG1; DKFZp586C1620; E3 ubiquitin-protein ligase Pirh2; h PRO1996; hPirh2; p53-induced protein with a RING-H2 domain; p53-induced RING-H2 protein; PIRH2E; PIRH2F; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; RING finger and CHY zinc finger domain-containing protein 1; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; zinc finger, CHY-type
Gene Aliases: ARNIP; CHIMP; PIRH2; PRO1996; RCHY1; RNF199; ZCHY; ZNF363
UniProt ID: (Human) B3KRG3
Entrez Gene ID: (Human) 25898
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support