Immunogen sequence: AQATSVPPAQ VQENQQANGH VSQDQEEPVY LESVARVPAE DETQSIDSED SFVPGRRASL SDLTDLEDIE GLTVRQLKEI LARNF
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CARP-2; CARP2; Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; FRING; FYVE-RING finger protein SAKURA; RIFIFYLIN; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RING-type E3 ubiquitin transferase rififylin; RNF189; RNF34L
Gene Aliases: CARP-2; CARP2; FRING; RFFL; RIFIFYLIN; RNF189; RNF34L
UniProt ID: (Human) Q8WZ73
Entrez Gene ID: (Human) 117584