Immunogen sequence: SPLQLTNIQV PQQALPTQRL VVQSAAPGSK GGQVSLTVHG TQQVHSPPEQ SPVQANSSSS KTAGAPTGTV PQQLQVHGVQ QSVPVTQ
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 87%.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
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Protein Aliases: EF-C; EFC; Enhancer factor C; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; Regulatory factor X 1; regulatory factor X, 1 (influences HLA class II expression); RFX; trans-acting regulatory factor 1; Transcription factor RFX1
Gene Aliases: EFC; RFX; RFX1
UniProt ID: (Human) P22670
Entrez Gene ID: (Human) 5989
Molecular Function: transcription factor