Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.
Protein Aliases: Regulatory factor X 4; regulatory factor X, 4 (influences HLA class II expression); Testis development protein NYD-SP10; Transcription factor RFX4; winged-helix transcription factor RFX4
Gene Aliases: NYD-SP10; RFX4
UniProt ID: (Human) Q33E94
Entrez Gene ID: (Human) 5992
Molecular Function: transcription factor