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Invitrogen
RFXAP Polyclonal Antibody
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FIGURE: 1 / 1
RFXAP Antibody (49-1034) in ChIP
ChIP assays were performed using NALM cells (a cell line derived from human pre-B leukemia), the anti-RFXAP antibody (Product # 49-1034), and optimized primer sets. Each ChIP assay used sheared chromatin from 2 million cells and 5 µg (lane 3) and 7 µg (lane 4) of anti-RFXAP antibody. An anti-flag antibody (lane 2) is used as negative IP control. The HLA_DRA primer pair was used as positive PCR control, and HLA_DOB was used a negative PCR control. The ChIP results using the anti-RFXAP antibody (Product # 49-1034) show a clear signal for the... View More
Product Details
49-1034
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Raised against the recombinant RFXAP protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.05% sodium azide, 0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Regulatory factor X-associated protein; RFX DNA-binding complex 36 kDa subunit; RFX-AP; RFX-associated protein; unnamed protein product
Gene Aliases: MHC2D4; RFXAP
UniProt ID: (Human) O00287
Entrez Gene ID: (Human) 5994
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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