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Product Details
PA5-51225
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein of human RHEBL1
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636673
Product Specific Information
The antibody detects endogenous levels of total RHEBL1 protein.
Target Information
RhebL1 (ras homolog enriched in brain-like protein 1), also known as Rheb2 or GTPase RhebL1, is a 183 amino acid protein that belongs to the small GTPase superfamily and Rheb family. Localizing to the cell membrane as well as the cytoplasm, RhebL1 is ubiquitously expressed and is increased two-fold in many tumor cell lines. RhebL1 exhibits GTPase activity and may activate NF-kappa-B-mediated gene transcription. Regulating the activity of Rictor, RhebL1 also promotes signal transduction. RhebL1 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 12q13.12 and mouse chromosome 15 F1. Human chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase RhebL1; Ras homolog enriched in brain like 1 c; Ras homolog enriched in brain like-1 c; Ras homolog enriched in brain-like protein 1; Rheb-like protein 1; Rheb2; RhebL1c
Gene Aliases: RHEBL1; RHEBL1c
UniProt ID: (Human) Q8TAI7
Entrez Gene ID: (Human) 121268
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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