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Proteintech
RHOG Polyclonal Antibody
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Product Details
19671-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to RHOG.
Target Information
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aplysia ras-related homolog G (RhoG); ARHG; ras homolog G (RhoG); ras homolog gene family, member G (rho G); Rho G; Rho-related GTP-binding protein RhoG; rhoG; Sid 10750; small GTP binding protein
Gene Aliases: 2810426G09Rik; ARHG; RHOG; Sid10750
UniProt ID: (Human) P84095, (Mouse) P84096
Entrez Gene ID: (Human) 391, (Mouse) 56212, (Rat) 308875
actin filament organization
establishment or maintenance of cell polarity
small GTPase mediated signal transduction
Rho protein signal transduction
positive regulation of cell proliferation
regulation of cell shape
Rac protein signal transduction
actin cytoskeleton organization
cortical cytoskeleton organization
regulation of actin cytoskeleton organization
positive regulation of transcription, DNA-templated
cell chemotaxis
activation of GTPase activity
regulation of postsynapse assembly
regulation of ruffle assembly
positive regulation of protein localization to plasma membrane
metabolic process
positive regulation of establishment of protein localization to plasma membrane
intracellular protein transport
nucleocytoplasmic transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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