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Invitrogen
RIP3 Polyclonal Antibody
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Product Details
PA5-80973
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human RIPK3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human RIPK3.
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: receptor interacting protein 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Ser/Thr kinase; unnamed protein product
Gene Aliases: RIP3; RIPK3
UniProt ID: (Human) Q9Y572
Entrez Gene ID: (Human) 11035
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
apoptotic process
signal transduction
positive regulation of metabolic process
regulation of gene expression
programmed cell death
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
protein modification process
NIK/NF-kappaB signaling
regulation of apoptotic process
T cell homeostasis
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
defense response to virus
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
cellular response to hydrogen peroxide
reactive oxygen species metabolic process
apoptotic signaling pathway
programmed necrotic cell death
necroptotic signaling pathway
execution phase of necroptosis
amyloid fibril formation
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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