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RMI2 is a protein coding gene, essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
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Protein Aliases: BLAP18; BLM-associated protein of 18 kDa; hRMI2; RecQ-mediated genome instability protein 2; RMI2, RecQ mediated genome instability 2, homolog
Gene Aliases: BLAP18; C16orf75; RMI2
UniProt ID: (Human) Q96E14
Entrez Gene ID: (Human) 116028
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