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Abnova
RNF14 Polyclonal Antibody, MaxPab™
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Product Details
H00009604-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNF14 (NP_899645.1, 1 a.a. approximately 348 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MQFLKEETLA YLNIVSPFEL KIGSQKKVQR RTAQASPNTE LDFGGAAGSD VDQEEIVDER AVQDVESLSN LIQEILDFDQ AQQIKCFNSK LFLCSICFCE KLGSECMYFL ECRHVYCKAC LKDYFEIQIR DGQVQCLNCP EPKCPSVATP GQVKELVEAE LFARYDRLLL QSSLDLMADV VYCPRPCCQL PVMQEPGCTM GICSSCNFAF CTLCRLTYHG VSPCKVTAEK LMDLRNEYLQ ADEANKRLLD QRYGKRVIQK ALEEMESKEW LEKNSKSCPC CGTPIEKLDG CNKMTCTGCM QYFCWICMGS LSRANPYKHF NDPGSPCFNR LFYAVDVDDD IWEDEVED
Target Information
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: androgen receptor associated protein 54; Androgen receptor-associated protein 54; E3 ubiquitin-protein ligase RNF14; HFB30; HRIHFB2038; RING finger protein 14; RNF14; unnamed protein product
Gene Aliases: ARA54; HFB30; HRIHFB2038; RNF14; TRIAD2
UniProt ID: (Human) Q9UBS8
Entrez Gene ID: (Human) 9604
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
translational elongation
translational termination
ubiquitin-dependent protein catabolic process
signal transduction
protein ubiquitination
androgen receptor signaling pathway
positive regulation of transcription, DNA-templated
regulation of androgen receptor signaling pathway
regulation of canonical Wnt signaling pathway
rescue of stalled ribosome
protein K6-linked ubiquitination
protein-RNA covalent cross-linking repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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