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Proteintech
RNF4 Polyclonal Antibody
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Product Details
17810-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNF4 Fusion Protein Ag12115 (1-190 aa encoded by BC031935)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTRKRRGG AINSRQAQKR TREATSTPEI SLEAEPIELV ETAGDEIVDL TCESLEPVVV DLTHNDSVVI VDERRRPRRN ARRLPQDHAD SCVVSSDDEE LSRDRDVYVT THTPRNARDE GATGLRPSGT VSCPICMDGY SEIVQNGRLI VSTECGHVFC SQCLRDSLKN ANTCPTCRKK INHKRYHPIY I (1-190 aa encoded by BC031935)
Target Information
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; Protein SNURF; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; SNURF; unnamed protein product
Gene Aliases: AU018689; Gtrgeo8; RES4-26; RNF4; SLX5; SNURF
UniProt ID: (Human) P78317, (Rat) O88846, (Mouse) Q9QZS2
Entrez Gene ID: (Human) 6047, (Rat) 29274, (Mouse) 19822
DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
nucleosome binding
SUMO polymer binding
identical protein binding
metal ion binding
ubiquitin protein ligase activity
transcription factor binding
ligase activity
TBP-class protein binding
estrogen receptor binding
progesterone receptor binding
androgen receptor binding
cellular response to DNA damage stimulus
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to arsenic-containing substance
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
regulation of spindle assembly
regulation of kinetochore assembly
negative regulation of protein localization to chromatin
transcription, DNA-templated
negative regulation of cell death
cellular response to gamma radiation
cellular response to hydroxyurea
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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