Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
RNF4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
17810-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNF4 Fusion Protein Ag12115 (1-190 aa encoded by BC031935)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTRKRRGG AINSRQAQKR TREATSTPEI SLEAEPIELV ETAGDEIVDL TCESLEPVVV DLTHNDSVVI VDERRRPRRN ARRLPQDHAD SCVVSSDDEE LSRDRDVYVT THTPRNARDE GATGLRPSGT VSCPICMDGY SEIVQNGRLI VSTECGHVFC SQCLRDSLKN ANTCPTCRKK INHKRYHPIY I (1-190 aa encoded by BC031935)
Target Information
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; Protein SNURF; RING finger protein 4; Small nuclear ring finger protein; SNURF
Gene Aliases: AU018689; Gtrgeo8; RES4-26; RNF4; SLX5; SNURF
UniProt ID: (Human) P78317, (Rat) O88846, (Mouse) Q9QZS2
Entrez Gene ID: (Human) 6047, (Rat) 29274, (Mouse) 19822
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
transcription factor binding
zinc ion binding
ligase activity
nucleosome binding
SUMO polymer binding
identical protein binding
androgen receptor binding
ubiquitin protein ligase activity
TBP-class protein binding
estrogen receptor binding
progesterone receptor binding
transcription, DNA-templated
protein ubiquitination
androgen receptor signaling pathway
negative regulation of protein sumoylation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to arsenic-containing substance
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
regulation of spindle assembly
regulation of kinetochore assembly
negative regulation of cell death
cellular response to gamma radiation
cellular response to hydroxyurea
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support