Immunogen sequence: REVLDGRQVVD MRTNPGDPRE AQEQQNDGKG RGNKAAKRDL PPAKTHLIQE DILPYCRPTF PTSNNPRDPS SSSSMSSRGS GSRQREQANV GRRNIAEMQV LG
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 89%.
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: axon guidance receptor; Deleted in U twenty twenty; DUTT1; FLJ21882; H-Robo-1; HGNC:10249; homolog 1 (Drosophila); MGC131599; MGC133277; ROBO1; roundabout; roundabout 1; Roundabout homolog 1; roundabout, axon guidance receptor, homolog 1; SAX3
Gene Aliases: DUTT1; ROBO1; SAX3
UniProt ID: (Human) Q9Y6N7
Entrez Gene ID: (Human) 6091
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor