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Invitrogen

ROC1 Recombinant Rabbit Monoclonal Antibody (R2D3)

View all (16) ROC1 antibodies

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Product Details

MA572231

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

R2D3

Immunogen

KLH conjugated synthetic peptide derived from human RBX1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Amount

26 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein transferase RBX1; RBX1; regulator of cullins 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; unnamed protein product; ZYP protein

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Gene Aliases: 1500002P15Rik; BA554C12.1; RNF75; ROC1

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UniProt ID: (Human) P62877, (Mouse) P62878

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Entrez Gene ID: (Human) 9978, (Mouse) 56438, (Rat) 300084

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Function(s)
ubiquitin-protein transferase activity protein binding zinc ion binding NEDD8 transferase activity ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding ubiquitin protein ligase activity NEDD8 ligase activity cullin family protein binding eukaryotic initiation factor 4E binding macromolecular complex binding
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter MAPK cascade protein polyubiquitination transcription-coupled nucleotide-excision repair nucleotide-excision repair regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process protein monoubiquitination cellular iron ion homeostasis cellular response to DNA damage stimulus spermatogenesis regulation of mitotic cell cycle cell proliferation regulation of autophagy regulation of cell cycle process regulation of centrosome duplication neural crest cell differentiation protein processing protein ubiquitination regulation of DNA-dependent DNA replication initiation regulation of BMP signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process replication fork processing regulation of TOR signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of type I interferon production regulation of natural killer cell activation cellular response to oxidative stress cellular response to UV regulation of gene expression, epigenetic T cell activation regulation of cell proliferation regulation of circadian rhythm signal transduction in response to DNA damage regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process post-translational protein modification protein K27-linked ubiquitination protein neddylation positive regulation of cilium assembly positive regulation of protein catabolic process negative regulation of smoothened signaling pathway regulation of embryonic development negative regulation of insulin receptor signaling pathway regulation of inflammatory response centrosome duplication regulation of cell cycle limb development cilium morphogenesis regulation of gene silencing by miRNA cellular response to chemical stress protein K63-linked ubiquitination protein K48-linked ubiquitination cellular response to amino acid stimulus regulation of cellular response to stress negative regulation of canonical Wnt signaling pathway ubiquitin-dependent protein catabolic process via the C-end degron rule pathway RNA polymerase II transcription initiation surveillance negative regulation of beige fat cell differentiation regulation of cellular response to insulin stimulus regulation of mitophagy negative regulation of macromitophagy regulation of cell cycle phase transition regulation of mitotic cytokinesis positive regulation of protein autoubiquitination negative regulation of response to oxidative stress negative regulation of adipose tissue development positive regulation of TORC1 signaling regulation of xenophagy ribosome-associated ubiquitin-dependent protein catabolic process regulation of DNA damage checkpoint regulation of stem cell population maintenance negative regulation of DNA-dependent DNA replication autophagosome assembly mitophagy epithelial to mesenchymal transition transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter apoptotic process response to oxidative stress lysosome organization insulin receptor signaling pathway negative regulation of autophagy positive regulation of autophagy protein catabolic process DNA damage response, signal transduction by p53 class mediator cellular response to nutrient levels negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of type I interferon production cellular response to insulin stimulus cellular response to amino acid starvation mRNA cleavage involved in gene silencing by miRNA p38MAPK cascade TORC1 signaling positive regulation of translation positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway base-excision repair, AP site formation via deaminated base removal negative regulation of signal transduction by p53 class mediator positive regulation of epithelial cell apoptotic process negative regulation of TORC1 signaling negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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