FIGURE: 1 / 6
Immunogen sequence: MAESLRSPR RSLYKLVGSP PWKEAFRQRC LERMRNSRDR LLNRYRQAGS SGPGNSQNSF LVQEVMEEEW NALQSVENCP EDLAQLEELI DMAVLEEIQQ ELINQEQSII SEYEKSLQFD EKCLSIMLAE WEANPLICPV CTNLLS (1-145 aa encoded by B C004451)
Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hRIP; nuclear transporter; RAP interaction protein; RPA interacting protein delta 2; RPA interacting protein epsilon; RPA-interacting protein
Gene Aliases: 2400006N03Rik; HRIP; RIP; RPAIN