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Invitrogen
RPL11 Polyclonal Antibody
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FIGURE: 1 / 3
RPL11 Antibody (PA5-101381) in ICC/IF
Immunofluorescent analysis of RPL11 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and RPL11 polyclonal antibody (Product # PA5-101381) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-101381
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RPL11, corresponding to a region within C-terminal amino acids.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RPL11.
Target Information
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60S ribosomal protein L11; cell growth-inhibiting protein 34; CLL-associated antigen KW-12; GIG34; Large ribosomal subunit protein uL5; RP11-223J15.3; unnamed protein product
Gene Aliases: 2010203J19Rik; DBA7; GIG34; L11; RPL11; uL5
UniProt ID: (Human) P62913, (Mouse) Q9CXW4, (Rat) P62914
Entrez Gene ID: (Human) 6135, (Mouse) 67025, (Rat) 362631
ribosomal large subunit assembly
cytoplasmic translation
rRNA processing
translation
protein targeting
positive regulation of gene expression
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
ribosomal large subunit biogenesis
protein stabilization
regulation of signal transduction by p53 class mediator
positive regulation of signal transduction by p53 class mediator
negative regulation of ubiquitin protein ligase activity
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of protein neddylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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