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Bioss

Rab3A+Rab3B+Rab3C+Rab3D Polyclonal Antibody

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Product Details

BS-6180R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Rab3A+Rab3B+Rab3C+Rab3D.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has four known isoforms: 3A, 3B, 3C and 3D. These proteins are expressed in the highest concentration in the brain and endocrine tissues and are involved in regulated exocytosis of hormones and neurotransmitters. Specifically Rab3's are thought to play a role in presynaptic vesicle trafficking and priming.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain antigen RAB3B; epididymis secretory sperm binding protein; glioblastoma overexpressed; Rab3D upregulated with myeloid differentiation; RAS-associated protein RAB3A; ras-like low molecular mass GTP-binding protein; Ras-related small GTP binding protein 3A; small GTP-binding protein Rab3C; small GTPase; unnamed protein product

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Gene Aliases: 2610528C18Rik; 2700062I01Rik; 3110015B08Rik; 3110037E15Rik; C130057E11Rik; D2-2; GOV; RAB16; RAB3; RAD3D; SCA52

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UniProt ID: (Human) P20336, (Human) P20337, (Human) Q96E17, (Human) O95716, (Rat) P63012, (Mouse) P63011, (Mouse) Q9CZT8, (Rat) Q63941, (Rat) P62824, (Mouse) P62823, (Rat) Q63942, (Mouse) P35276

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Entrez Gene ID: (Human) 5864, (Human) 5865, (Human) 115827, (Human) 9545, (Rat) 25531, (Mouse) 19339, (Mouse) 69908, (Rat) 81755, (Rat) 171058, (Mouse) 67295, (Rat) 140665, (Mouse) 19340

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding protein binding, bridging GTP-dependent protein binding myosin V binding GDP binding ATPase activator activity GDP-dissociation inhibitor binding ATPase binding
Process(es)
exocytosis regulation of exocytosis peptidyl-cysteine methylation antigen processing and presentation positive regulation of dopamine uptake involved in synaptic transmission regulation of vesicle size regulation of synaptic vesicle cycle bone resorption positive regulation of regulated secretory pathway plasma membrane repair respiratory system process mitochondrion organization neuromuscular synaptic transmission axonogenesis post-embryonic development regulation of synaptic vesicle priming regulation of dopamine secretion synaptic vesicle exocytosis synaptic vesicle maturation calcium ion regulated exocytosis insulin secretion lung development regulation of synaptic vesicle fusion to presynaptic membrane lysosome localization Rab protein signal transduction synaptic vesicle recycling regulated exocytosis regulation of short-term neuronal synaptic plasticity synaptic vesicle transport maintenance of presynaptic active zone structure sensory perception of touch response to electrical stimulus acrosomal vesicle exocytosis evoked neurotransmitter secretion synaptic vesicle clustering regulation of presynaptic dense core granule exocytosis regulation of plasma membrane repair regulation of synaptic vesicle exocytosis constitutive secretory pathway positive regulation of exocytosis regulation of long-term synaptic potentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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