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Bioss

Rab3A+Rab3B+Rab3C+Rab3D Polyclonal Antibody

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Product Details

BS-6180R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Rab3A+Rab3B+Rab3C+Rab3D.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has four known isoforms: 3A, 3B, 3C and 3D. These proteins are expressed in the highest concentration in the brain and endocrine tissues and are involved in regulated exocytosis of hormones and neurotransmitters. Specifically Rab3's are thought to play a role in presynaptic vesicle trafficking and priming.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain antigen RAB3B; epididymis secretory sperm binding protein; glioblastoma overexpressed; GTP-binding protein Rab-3D; Rab3D upregulated with myeloid differentiation; RAS-associated protein RAB3A; Ras-related protein Rab-3A; Ras-related protein Rab-3B; Ras-related protein Rab-3C; Ras-related protein Rab-3D; Ras-related small GTP binding protein 3A; small GTP-binding protein Rab3C; unnamed protein product

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Gene Aliases: 2610528C18Rik; 2700062I01Rik; 3110015B08Rik; 3110037E15Rik; AI850886; C130057E11Rik; D2-2; GOV; RAB16; RAB3; RAB3A; RAB3B; RAB3C; RAB3D; RAD3D

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UniProt ID: (Human) P20336, (Human) P20337, (Human) Q96E17, (Human) O95716, (Rat) P63012, (Mouse) P63011, (Mouse) Q9CZT8, (Rat) Q63941, (Rat) P62824, (Mouse) P62823, (Mouse) P35276, (Rat) Q63942

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Entrez Gene ID: (Human) 5864, (Human) 5865, (Human) 115827, (Human) 9545, (Rat) 25531, (Mouse) 19339, (Mouse) 69908, (Rat) 81755, (Rat) 171058, (Mouse) 67295, (Mouse) 19340, (Rat) 140665

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Function(s)
nucleotide binding GTPase activity protein binding GTP binding hydrolase activity protein binding, bridging GTP-dependent protein binding myosin V binding metal ion binding GDP binding ATPase activator activity protein C-terminus binding GTPase binding ATPase binding
Process(es)
exocytosis protein transport regulation of exocytosis antigen processing and presentation positive regulation of dopamine uptake involved in synaptic transmission regulation of vesicle size regulation of synaptic vesicle cycle bone resorption positive regulation of regulated secretory pathway intracellular protein transport vesicle docking involved in exocytosis metabolic process protein secretion synaptic vesicle exocytosis Rab protein signal transduction protein localization to plasma membrane respiratory system process mitochondrion organization neuromuscular synaptic transmission axonogenesis post-embryonic development synaptic vesicle maturation lung development regulation of synaptic vesicle fusion to presynaptic membrane positive regulation of ATPase activity synaptic vesicle recycling regulation of short-term neuronal synaptic plasticity maintenance of presynaptic active zone structure sensory perception of touch response to electrical stimulus plasma membrane repair calcium ion regulated exocytosis insulin secretion lysosome localization constitutive secretory pathway regulated exocytosis positive regulation of exocytosis synaptic vesicle transport establishment of localization in cell acrosomal vesicle exocytosis evoked neurotransmitter secretion synaptic vesicle clustering regulation of presynaptic dense core granule exocytosis regulation of plasma membrane repair transport small GTPase mediated signal transduction peptidyl-cysteine methylation regulation of long-term synaptic potentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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