Peptide sequence: MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ
Sequence homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
RABGEF1 forms a complex with rabaptin-5 (RABPT5) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5.
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Protein Aliases: RAB guanine nucleotide exchange factor (GEF) 1; Rab5 exchange factor; Rab5 GDP/GTP exchange factor; Rab5 guanine nucleotide exchange factor Rabex-5; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RAP1; Ras negative regulator Rabex-5; Ras negative regulator Rabex-5/Rin2
Gene Aliases: BOS_22847; Rab5ef; rabex-5; RABEX5; RABGEF1; RAP1; Rin2; zgc:65944
Molecular Function: enzyme modulator