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Invitrogen
RbAp46 Polyclonal Antibody
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Product Details
PA1-868
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-868 detects retinoblastoma protein (Rb) associated protein 46 (RbAp46) from human cells.
PA1-868 has been successfully used in IF, Western blot and immunocytochemical procedures. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 from HeLa cell lysate. Immunocytochemical staining of RbAp46 in HeLa cells with PA1-868 results in nuclear staining.
The PA1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. This immunizing peptide (Cat. # PEP-083) is available for use in neutralization and control experiments.
Target Information
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
Gene Aliases: RBAP46; RBBP7
UniProt ID: (Human) Q16576
Entrez Gene ID: (Human) 5931
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription, DNA-templated
multicellular organism development
cell proliferation
histone deacetylation
negative regulation of cell growth
CENP-A containing nucleosome assembly
negative regulation of gene expression, epigenetic
response to steroid hormone
cellular heat acclimation
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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