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Product Details
602-880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the epitope -CDTAV- without a phosphorylation site Thr396 of human RockII protein
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
Positive control: 3T3 cells
Target Information
ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p150 ROK-alpha; p164 ROCK-2; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK II; ROCK-II; ROCK2; protein kinase; rockii; ROKalpha
Gene Aliases: B230113H15Rik; KIAA0619; mKIAA0619; Rho-kinase; ROCK-II; ROCK2; Rock2m; ROK; ROKalpha
UniProt ID: (Bovine) Q28021, (Human) O75116, (Rat) Q62868, (Mouse) P70336
Entrez Gene ID: (Bovine) 282041, (Dog) 482970, (Chicken) 374182, (Human) 9475, (Rat) 25537, (Mouse) 19878
Molecular Function:
non-receptor serine/threonine protein kinase
smooth muscle contraction
positive regulation of centrosome duplication
actin cytoskeleton organization
regulation of actin cytoskeleton organization
regulation of circadian rhythm
rhythmic process
cytokinesis
positive regulation of protein phosphorylation
protein phosphorylation
I-kappaB kinase/NF-kappaB signaling
Rho protein signal transduction
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of angiogenesis
regulation of cell adhesion
cortical actin cytoskeleton organization
negative regulation of myosin-light-chain-phosphatase activity
regulation of keratinocyte differentiation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
centrosome duplication
regulation of stress fiber assembly
regulation of focal adhesion assembly
cellular response to testosterone stimulus
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
regulation of establishment of cell polarity
regulation of cell motility
neural tube closure
extrinsic apoptotic signaling pathway via death domain receptors
chromosome condensation
dendrite morphogenesis
phosphorylation
intracellular signal transduction
protein kinase activity
protein serine/threonine kinase activity
ATP binding
metal ion binding
structural molecule activity
protein binding
Rho GTPase binding
poly(A) RNA binding
Rho-dependent protein serine/threonine kinase activity
kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
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