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Product Details
PA5-120669
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RHOG (NP_001656.2).
Conjugate
Form
Liquid
Concentration
2.35 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914241
Product Specific Information
Immunogen sequence: TVNLNLWDTA GQEEYDRLRT LSYPQTNVFV ICFSIASPPS YENVRHKWHP EVCHHCPDVP ILLVGTKKDL RAQPDTLRRL KEQGQAPITP QQGQALAKQI H
Target Information
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aplysia ras-related homolog G (RhoG); ras homolog G (RhoG); ras homolog gene family, member G (rho G); Rho G; Rho-related GTP-binding protein RhoG; Sid 10750
Gene Aliases: 2810426G09Rik; ARHG; RHOG; Sid10750
UniProt ID: (Human) P84095, (Mouse) P84096
Entrez Gene ID: (Human) 391, (Mouse) 56212, (Rat) 308875
Rho protein signal transduction
positive regulation of cell proliferation
Rac protein signal transduction
actin cytoskeleton organization
platelet activation
positive regulation of transcription, DNA-templated
regulation of small GTPase mediated signal transduction
cell chemotaxis
positive regulation of establishment of protein localization to plasma membrane
activation of GTPase activity
regulation of ruffle assembly
small GTPase mediated signal transduction
metabolic process
intracellular protein transport
nucleocytoplasmic transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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