This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: EHNGMRGLIP HKYITLPAGT EKQVVGAGLQ TAGESGSSPE GLLASELVHR PEPCTSPEAM GPSGHRRRCL VPASPEQHVE VDKAVAQNMD SVFKELLGKT SVRQGLGPAS TTSP
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 72%.
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: GTPase-activating protein p115; p115; RG RhoGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4
Gene Aliases: A130009C12Rik; A530015A20Rik; ARHGAP4; C1; KIAA0131; mKIAA0131; p115; RGC1; RHOGAP4; SrGAP4
UniProt ID: (Human) P98171