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Ribeye Polyclonal Antibody

Ribeye Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Ribeye Antibody (OSR00339W-100UL) in IHC (P)

IHC-P on paraffin sections of rat spleen. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions.... View More

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Product Details

OSR00339W-100UL

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the c-terminal region of human Ribeye (CTBP2, C-terminal-binding protein 2) conjugated to an immunogenic carrier protein was used as the antigen

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: CTBP2.

Target Information

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Science (New York, N.Y.)

Matsuoka S,Ballif BA,Smogorzewska A,McDonald ER,Hurov KE,Luo J,Bakalarski CE,Zhao Z,Solimini N,Lerenthal Y,Shiloh Y,Gygi SP,Elledge SJ

Fri May 25 00:00:00 UTC 2007

The full-ORF clone resource of the German cDNA Consortium.

BMC genomics

Bechtel S,Rosenfelder H,Duda A,Schmidt CP,Ernst U,Wellenreuther R,Mehrle A,Schuster C,Bahr A,Blöcker H,Heubner D,Hoerlein A,Michel G,Wedler H,Köhrer K,Ottenwälder B,Poustka A,Wiemann S,Schupp I

Wed Oct 31 00:00:00 UTC 2007

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nature genetics

Ota T,Suzuki Y,Nishikawa T,Otsuki T,Sugiyama T,Irie R,Wakamatsu A,Hayashi K,Sato H,Nagai K,Kimura K,Makita H,Sekine M,Obayashi M,Nishi T,Shibahara T,Tanaka T,Ishii S,Yamamoto J,Saito K,Kawai Y,Isono Y,Nakamura Y,Nagahari K,Murakami K,Yasuda T,Iwayanagi T,Wagatsuma M,Shiratori A,Sudo H,Hosoiri T,Kaku Y,Kodaira H,Kondo H,Sugawara M,Takahashi M,Kanda K,Yokoi T,Furuya T,Kikkawa E,Omura Y,Abe K,Kamihara K,Katsuta N,Sato K,Tanikawa M,Yamazaki M,Ninomiya K,Ishibashi T,Yamashita H,Murakawa K,Fujimori K,Tanai H,Kimata M,Watanabe M,Hiraoka S,Chiba Y,Ishida S,Ono Y,Takiguchi S,Watanabe S,Yosida M,Hotuta T,Kusano J,Kanehori K,Takahashi-Fujii A,Hara H,Tanase TO,Nomura Y,Togiya S,Komai F,Hara R,Takeuchi K,Arita M,Imose N,Musashino K,Yuuki H,Oshima A,Sasaki N,Aotsuka S,Yoshikawa Y,Matsunawa H,Ichihara T,Shiohata N,Sano S,Moriya S,Momiyama H,Satoh N,Takami S,Terashima Y,Suzuki O,Nakagawa S,Senoh A,Mizoguchi H,Goto Y,Shimizu F,Wakebe H,Hishigaki H,Watanabe T,Sugiyama A,Takemoto M,Kawakami B,Yamazaki M,Watanabe K,Kumagai A,Itakura S,Fukuzumi Y,Fujimori Y,Komiyama M,Tashiro H,Tanigami A,Fujiwara T,Ono T,Yamada K,Fujii Y,Ozaki K,Hirao M,Ohmori Y,Kawabata A,Hikiji T,Kobatake N,Inagaki H,Ikema Y,Okamoto S,Okitani R,Kawakami T,Noguchi S,Itoh T,Shigeta K,Senba T,Matsumura K,Nakajima Y,Mizuno T,Morinaga M,Sasaki M,Togashi T,Oyama M,Hata H,Watanabe M,Komatsu T,Mizushima-Sugano J,Satoh T,Shirai Y,Takahashi Y,Nakagawa K,Okumura K,Nagase T,Nomura N,Kikuchi H,Masuho Y,Yamashita R,Nakai K,Yada T,Nakamura Y,Ohara O,Isogai T,Sugano S

Thu Jan 01 00:00:00 UTC 2004

The DNA sequence and comparative analysis of human chromosome 20.

Nature

Deloukas P,Matthews LH,Ashurst J,Burton J,Gilbert JG,Jones M,Stavrides G,Almeida JP,Babbage AK,Bagguley CL,Bailey J,Barlow KF,Bates KN,Beard LM,Beare DM,Beasley OP,Bird CP,Blakey SE,Bridgeman AM,Brown AJ,Buck D,Burrill W,Butler AP,Carder C,Carter NP,Chapman JC,Clamp M,Clark G,Clark LN,Clark SY,Clee CM,Clegg S,Cobley VE,Collier RE,Connor R,Corby NR,Coulson A,Coville GJ,Deadman R,Dhami P,Dunn M,Ellington AG,Frankland JA,Fraser A,French L,Garner P,Grafham DV,Griffiths C,Griffiths MN,Gwilliam R,Hall RE,Hammond S,Harley JL,Heath PD,Ho S,Holden JL,Howden PJ,Huckle E,Hunt AR,Hunt SE,Jekosch K,Johnson CM,Johnson D,Kay MP,Kimberley AM,King A,Knights A,Laird GK,Lawlor S,Lehvaslaiho MH,Leversha M,Lloyd C,Lloyd DM,Lovell JD,Marsh VL,Martin SL,McConnachie LJ,McLay K,McMurray AA,Milne S,Mistry D,Moore MJ,Mullikin JC,Nickerson T,Oliver K,Parker A,Patel R,Pearce TA,Peck AI,Phillimore BJ,Prathalingam SR,Plumb RW,Ramsay H,Rice CM,Ross MT,Scott CE,Sehra HK,Shownkeen R,Sims S,Skuce CD,Smith ML,Soderlund C,Steward CA,Sulston JE,Swann M,Sycamore N,Taylor R,Tee L,Thomas DW,Thorpe A,Tracey A,Tromans AC,Vaudin M,Wall M,Wallis JM,Whitehead SL,Whittaker P,Willey DL,Williams L,Williams SA,Wilming L,Wray PW,Hubbard T,Durbin RM,Bentley DR,Beck S,Rogers J

Thu Jan 31 00:00:00 UTC 2002

RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.

Neuron

Schmitz F,Königstorfer A,Südhof TC

Fri Dec 01 00:00:00 UTC 2000

Bioinformatics

Protein Aliases: C-terminal-binding protein 2; CtBP2; gene trap ROSA b-geo 6; ribeye; RP11-59C5.2

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Gene Aliases: AA407280; CTBP2; D7Ertd45e; Gtrgeo6; Ribeye

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UniProt ID: (Human) A8K2X5, (Rat) Q9EQH5, (Mouse) P56546

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Entrez Gene ID: (Human) 1488, (Rat) 81717, (Mouse) 13017

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Function(s)

chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity retinoic acid receptor binding NAD binding oxidoreductase activity transcription cofactor

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated negative regulation of cell proliferation viral genome replication positive regulation of chromatin binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of retinoic acid receptor signaling pathway white fat cell differentiation oxidation-reduction process regulation of transcription, DNA-templated metabolic process cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Ribeye Polyclonal Antibody

Ribeye Antibody (OSR00339W-100UL) in IHC (P)

Product Details

OSR00339W-100UL

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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