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Ribeye Polyclonal Antibody
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FIGURE: 1 / 6
Ribeye Antibody (OSR00339W-100UL) in IHC (P)
IHC-P on paraffin sections of rat spleen. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions.... View More
Product Details
OSR00339W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the c-terminal region of human Ribeye (CTBP2, C-terminal-binding protein 2) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: CTBP2.
Target Information
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-terminal-binding protein 2; CTBP2; gene trap ROSA b-geo 6; phosphoprotein; CtBP; transcriptional corepressor; ribeye; RP11-59C5.2; unnamed protein product
Gene Aliases: AA407280; CTBP2; D7Ertd45e; Gtrgeo6; Ribeye
UniProt ID: (Human) P56545, (Rat) Q9EQH5, (Mouse) P56546
Entrez Gene ID: (Human) 1488, (Rat) 81717, (Mouse) 13017
transcription cofactor binding
transcription corepressor binding
transcription coactivator activity
transcription corepressor activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein kinase binding
identical protein binding
macromolecular complex binding
NAD binding
DNA-binding transcription factor binding
chromatin binding
retinoic acid receptor binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
viral genome replication
cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
white fat cell differentiation
transcription, DNA-templated
positive regulation of chromatin binding
oxidation-reduction process
regulation of transcription, DNA-templated
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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