The recommended shelf life for this product is 1 year from date of receipt.
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: probable E3 ubiquitin-protein ligase Roquin; Protein Sanroque; RC3H1; RING finger and C3H zinc finger protein 1; Ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; RING finger protein 198; RNF198; Roquin; Roquin-1
Gene Aliases: 5730557L09Rik; Gm551; KIAA2025; mKIAA2025; N28103; RC3H1; RNF198; ROQUIN