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Invitrogen
Rubicon Polyclonal Antibody
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Product Details
PA5-62974
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Rubicon. Recombinant protein control fragment (Product #RP-100145).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSHSDTSIAS RGAPESCNDK AKLRGPLPYS GQSSEVSTPS SLYMEYEGGR YLCSGEGMFR RPSEGQSLIS YLSEQDFGSC ADLEKENAHF S
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 64%.
Target Information
Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Baron; Beclin-1 associated RUN domain containing protein; Rubicon; RUN and cysteine rich domain containing beclin 1 interacting protein; RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; rundataxin; unnamed protein product
Gene Aliases: KIAA0226; RUBCN; RUBICON; SCAR15
UniProt ID: (Human) Q92622
Entrez Gene ID: (Human) 9711
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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