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Invitrogen
Her-2/CD4 (Runimotamab Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-54985
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant Human CD340/ERBB2/HER2 and CD3E.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
HER2, also known as ErbB2, is a member of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases. Unlike other family members, HER2 has no known direct ligand and functions primarily through heterodimerization with other ErbB receptors, leading to activation of downstream signaling pathways such as PI3K/AKT and MAPK that regulate cell proliferation, survival, and differentiation. HER2 is overexpressed or amplified in several cancers, most notably breast and gastric cancers, where it is associated with aggressive disease and poor prognosis. Due to its role in tumor growth and its cell surface accessibility, HER2 is an important target for monoclonal antibodies, antibody-drug conjugates, and other targeted therapies.
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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