This S100A11 antibody (10237-1-AP) has also been instrumental in investigations into S100A11's role in the development of brain tumors in tuberous sclerosis complex (TSC) patients.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
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Protein Aliases: Calgizzarin; calizzarin; EMAP; endothelial monocyte activating polypeptide 1; Endothelial monocyte-activating polypeptide; epididymis secretory protein Li 43; Metastatic lymph node gene 70 protein; MLN 70; Protein S100-A11; Protein S100-A11, N-terminally processed; Protein S100-C; Protein S100C; S100 calcium binding protein A11 (calizzarin); S100 calcium binding protein A14; S100 calcium-binding protein A11; S100 calcium-binding protein A11 (calgizzarin)
Gene Aliases: cal; Emap1; EMAPI; HEL-S-43; MLN70; S100A11; S100a14; S100C