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SAP102 Polyclonal Antibody
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Product Details
OSS00212W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of human SAP102 (DLG3) conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 95% identity with rat and mouse sequences.
Specificity of this antibody: SAP102.
Target Information
Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: discs, large homolog 3; neuroendocrine-DLG; protein phosphatase 1, regulatory subunit 82; PSD-95/SAP90-related protein 1; SAP-102; SAP102; synapse-associated protein 102; unnamed protein product
Gene Aliases: Dlgh3; mKIAA1232; MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90; XLMR
UniProt ID: (Human) Q92796, (Rat) Q62936, (Mouse) P70175
Entrez Gene ID: (Human) 1741, (Rat) 58948, (Mouse) 53310
establishment of planar polarity
chemical synaptic transmission
nervous system development
protein localization to synapse
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
receptor localization to synapse
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of postsynaptic density structure
negative regulation of cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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