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Invitrogen
SAP102 Polyclonal Antibody
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Product Details
PA5-118909
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DLG3(Accession Q92796), corresponding to amino acid residues D638-D688.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DLG3.
Target Information
Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: discs large homolog 3; discs, large homolog 3; Disks large homolog 3; Neuroendocrine-DLG; protein phosphatase 1, regulatory subunit 82; PSD-95/SAP90-related protein 1; SAP-102; SAP102; Synapse-associated protein 102; unnamed protein product; XLMR
Gene Aliases: DLG3; Dlgh3; KIAA1232; mKIAA1232; MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90; XLMR
UniProt ID: (Human) Q92796, (Rat) Q62936, (Mouse) P70175
Entrez Gene ID: (Human) 1741, (Rat) 58948, (Mouse) 53310
protein binding
kinase binding
protein kinase binding
phosphatase binding
ubiquitin protein ligase binding
ionotropic glutamate receptor binding
guanylate kinase activity
protein C-terminus binding
protein phosphatase binding
protein domain specific binding
PDZ domain binding
scaffold/adaptor protein
establishment of planar polarity
chemical synaptic transmission
nervous system development
negative regulation of cell proliferation
protein localization to synapse
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
receptor localization to synapse
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
negative regulation of phosphatase activity
nucleotide phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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