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Invitrogen
SARM Polyclonal Antibody
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Product Details
PA5-143637
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length recombinant human SARM1 protein
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 150mM NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specific for endogenous levels of the ~79 kDa SARM1 protein.
Target Information
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ36296; HsTIR; MyD88-5; NAD(+) hydrolase SARM1; NADase SARM1; NADP(+) hydrolase SARM1; SAM domain-containing protein 2; SARM1a; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; Sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog; unnamed protein product
Gene Aliases: A830091I15Rik; C78606; hSARM1; HsTIR; KIAA0524; MyD88-5; MyD885; SAMD2; SARM; SARM1
UniProt ID: (Human) Q6SZW1, (Rat) D3ZUM2, (Mouse) Q6PDS3
Entrez Gene ID: (Human) 23098, (Rat) 287545, (Mouse) 237868
immune system process
signal transduction
nervous system development
response to glucose
NAD catabolic process
cell differentiation
negative regulation of MyD88-independent toll-like receptor signaling pathway
regulation of neuron apoptotic process
innate immune response
response to axon injury
regulation of dendrite morphogenesis
neurological system process
protein localization to mitochondrion
modification of postsynaptic structure
regulation of synapse pruning
regulation of apoptotic process
regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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