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Invitrogen
SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Rabbit Monoclonal Antibody (P05DHuRb)
FIGURE: 1 / 10
SARS-CoV-2 Spike Protein (RBD) Chimeric Antibody (703971) in ICC/IF
For Immunofluorescence analysis, HEK-293 cells were transfected with a vector encoding full length spike protein from SARS CoV2. Cells were fixed and permeabilized for detection of spike protein using Anti-SARS CoV2 Spike Protein RBD Recombinant Rabbit Chimera Monoclonal Antibody (Product # 703971) at a concentration of 5 µg/mL and labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Anti... View More
Product Details
703971
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
P05DHuRb
Immunogen
This antibody was developed using computationally derived variants of SARS-CoV antibody structures and is shown to bind Spike Protein S1 subunit (RBD) of SARS CoV2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2866480
Product Specific Information
This antibody has a human Fab with a kappa light chain, and Rabbit Fc. It recognizes the RBD domain of SARS CoV2 Spike protein.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
This antibody is not recommended for the Western blot application.
This antibody is not recommended for the Neutralization application.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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