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Product Details
22675-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SART1 Fusion Protein Ag18478 (451-800 aa encoded by BC001058)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes the endogenous 800-amino acid SART1, which migrates with an apparent molecular mass of 110 kDa in SDS-PAGE.
Immunogen sequence: EEEKEPVPQ PLPSDDTRVE NMDISDEEEG GAPPPGSPQV LEEDEAELEL QKQLEKGRRL RQLQQLQQLR DSGEKVVEIV KKLESRQRGW EEDEDPERKG AIVFNATSEF CRTLGEIPTY GLAGNREEQE ELMDFERDEE RSANGGSESD GEENIGWSTV NLDEEKQQQD FSASSTTILD EEPIVNRGLA AALLLCQNKG LLETTVQKVA RVKAPNKSLP SAVYCIEDKM AIDDKYSRRE EYRGFTQDFK EKDGYKPDVK IEYVDETGRK LTPKEAFRQL SHRFHGKGSG KMKTERRMKK LDEEALLKKM SSSDTPLGTV ALLQEKQKAQ KTPYIVLSGS GKSMNANTIT K (451-800 aa encoded by BC001058)
Target Information
This gene encodes two proteins, the SART1protein expressed in the nucleus of the majority of proliferating cells, and the SART1protein expressed in the cytosol of epithelial cancers. The SART1protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hSART-1; hSnu66; Hypoxia-associated factor; IgE autoantigen; MGC2038; mSART-1; SART-1; SART1(259) protein; SART1(800) protein; small nuclear ribonucleoprotein 110kDa (U4/U6.U5); SNU66 homolog; squamous cell carcinoma antigen recognised by T cells; squamous cell carcinoma antigen recognized by T cells 1; Squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; U4/U6.U5 tri-snRNP-associated protein 1
Gene Aliases: Ara1; Haf; HOMS1; SART1; SART1259; SNRNP110; Snu66; U5-110K
UniProt ID: (Human) O43290, (Mouse) Q9Z315
Entrez Gene ID: (Human) 9092, (Mouse) 20227
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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