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SATB2 Polyclonal Antibody
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Product Details
BS-11949R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SATB2, amino acids 451-485.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034-like DNA binding protein; MGC119474; MGC119477; SATB family member 2; SATB2 fusion; special AT-rich sequence binding protein 2; Special AT-rich sequence-binding protein 2; truncated protein after SATB2; two cut domains-containing homeodomain protein; unnamed protein product
Gene Aliases: C2DELq32q33; DEL2Q32Q33; GLSS; KIAA1034; mKIAA1034; RGD1562369; SATB2
UniProt ID: (Human) Q3ZB87, (Mouse) Q8VI24
Entrez Gene ID: (Human) 23314, (Mouse) 212712, (Rat) 501145
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
histone deacetylase binding
sequence-specific DNA binding
helix-turn-helix transcription factor
DNA-binding transcription factor
Lambda repressor-like transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
neuron migration
osteoblast development
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
embryonic pattern specification
regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
cartilage development
palate development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
commitment of neuronal cell to specific neuron type in forebrain
cellular response to organic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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