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Product Details
PA5-70330
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the C-terminal region of SAV1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2691157
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Target Information
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 45 kDa WW domain protein; mWW45; Protein salvador homolog 1; WW domain-containing protein 3; WW domain-containing protein 4
Gene Aliases: 1700040G09Rik; Salv; Sav; Sav1; WW45; Wwp3; Wwp4
UniProt ID: (Mouse) Q8VEB2
Entrez Gene ID: (Mouse) 64010
hair follicle development
signal transduction
keratinocyte differentiation
hippo signaling
positive regulation of apoptotic process
positive regulation of fat cell differentiation
regulation of organ growth
negative regulation of epithelial cell proliferation
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of cardiac muscle cell proliferation
ventricular septum morphogenesis
lung epithelial cell differentiation
intestinal epithelial cell differentiation
regulation of stem cell population maintenance
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