Bioss

SCAP2 Polyclonal Antibody

View all (11) SKAP2 antibodies

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Datasheet

Protocols

Questions & Answers

Tech Support

Product Details

BS-13673R

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-
Immunohistochemistry (Frozen) (IHC (F))	1:100-1:500	-
Immunocytochemistry (ICC/IF)	1:100-1:500	-
ELISA (ELISA)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide derived from human SCAP2, amino acids 1-100. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS with 1% BSA, 50% glycerol
Contains	0.09% sodium azide
Storage conditions	-20°C

Target Information

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP-55HOM; SKAP-HOM; SKAP55 homolog; SKAP55 homologue; SKAP55-HOM; src family associated phosphoprotein 2; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; Src-associated adapter protein with PH and SH3 domains; Src-associated adaptor protein

Gene Aliases: 2610021A10Rik; AA960083; BB137539; mSKAP55R; PRAP; RA70; SAPS; SCAP2; Scap55r; SKAP-HOM; SKAP2; SKAP55R

UniProt ID: (Human) O75563, (Rat) Q920G0, (Mouse) Q3UND0

Entrez Gene ID: (Human) 8935, (Rat) 155183, (Mouse) 54353

Molecular Function: scaffold/adaptor protein immunoglobulin