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Immunogen sequence: MPGPATDAGK IPFCDAKEEI RAGLESSEGG GGPERPGARG QRQNIVWRNV VLMSLLHLGA VYSLVLIPKA KPLTL; Positive Samples: U-87MG, 293T; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
Stearoyl-CoA desaturase is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acyl-CoA-desaturase 4; HSCD5; Stearoyl-CoA 9-desaturase; Stearoyl-CoA desaturase 2; stearoyl-CoA desaturase 4; Stearoyl-CoA desaturase 5
Gene Aliases: ACOD4; FADS4; HSCD5; SCD2; SCD4; SCD5
UniProt ID: (Human) Q86SK9
Entrez Gene ID: (Human) 79966
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