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Rockland
SCF Polyclonal Antibody
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FIGURE: 1 / 3
SCF Antibody (600-401-EE1) in ICC/IF
Immunofluorescence Microscopy of SCF antibody. Tissue: Human brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: SCF antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: SCF is a membrane protein. Staining: SCF as red fluorescent signal.
Product Details
600-401-EE1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-SCF antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide from near the internal region of human SCF.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-kit ligand; cloud gray; DKFZp686F2250; familial progressive hyperpigmentation 2; grizzle-belly; H-SCF; Hematopoietic growth factor KL; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1
Gene Aliases: blz; Clo; Con; contrasted; DCUA; DFNA69; FPH2; FPHH; Gb; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; Sl; SLF
UniProt ID: (Human) P21583, (Mouse) P20826, (Rat) P21581
Entrez Gene ID: (Human) 4254, (Mouse) 17311, (Rat) 60427
MAPK cascade
ovarian follicle development
neural crest cell migration
positive regulation of leukocyte migration
positive regulation of myeloid leukocyte differentiation
cell adhesion
signal transduction
cell proliferation
male gonad development
regulation of phosphatidylinositol 3-kinase signaling
negative regulation of mast cell apoptotic process
embryonic hemopoiesis
ectopic germ cell programmed cell death
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of melanocyte differentiation
positive regulation of DNA replication
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of mast cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of hematopoietic stem cell proliferation
germ cell development
positive regulation of cell proliferation
negative regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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