For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
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Protein Aliases: Sec1 family domain-containing protein 1; SLY1 homolog; Sly1p; Syntaxin-binding protein 1-like 2; vesicle transport-related protein; Vesicle transport-related protein Ra410
Gene Aliases: 3110021P21Rik; C14orf163; FKSG23; KIAA0917; RA410; rSly1; SCFD1; SLY1; SLY1P; STXBP1L2
Molecular Function: membrane trafficking regulatory protein