Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
SCIN Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
11579-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCIN Fusion Protein Ag2168 (1-357 aa encoded by BC021090)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MARELYHEE FARAGKQAGL QVWRIEKLEL VPVPQSAHGD FYVGDAYLVL HTAKTSRGFT YRLHFWLGKE CSQDESTAAA IFTVQMDDYL GGKPVQNREL QGYESNDFVS YFKGGLKYKA GGVASGLNHV LTNDLTAKRL LHVKGRRVVR ATEVPLSWDS FNKGDCFIID LGTEIYQWCG SSCNKYERLK ANQVATGIRY NERKGRSELI VVEEGSEPSE LIKVLGEKPE LPDGGDDDDI IADISNRKMA KLYMVSDASG SMRVTVVAEE NPFSMAMLLS EECFILDHGA AKQIFVWKGK DANPQERKAA MKTAEEFLQQ MNYSKNTQIQ VLPEGGETPI FKQFFKDWRD KDQSDGFG (1-357 aa encoded by BC021090)
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adseverin; Gelsolin-like protein; Scinderin
Gene Aliases: adseverin; AW545522; KIAA1905; SCIN; Scind
UniProt ID: (Human) Q9Y6U3, (Mouse) Q60604
Entrez Gene ID: (Human) 85477, (Rat) 298975, (Mouse) 20259
negative regulation of cell proliferation
calcium ion regulated exocytosis
regulation of chondrocyte differentiation
sequestering of actin monomers
positive regulation of apoptotic process
actin nucleation
positive regulation of megakaryocyte differentiation
actin filament severing
positive regulation of secretion
positive regulation of actin nucleation
actin filament capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support