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Proteintech
SCLY Polyclonal Antibody
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Product Details
10667-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCLY Fusion Protein Ag0972 (145-445 aa encoded by BC007891)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects the N-terminal of the protein.
Immunogen sequence: HDSIRLPLE HLVEEQVAAV TFVPVSKVSG QTEVDDILAA VRPTTRLVTI MLANNETGIV MPVPEISQRI KALNQERVAA GLPPILVHTD AAQALGKQRV DVEDLGVDFL TIVGHKFYGP RIGALYIRGL GEFTPLYPML FGGGQERNFR PGTENTPMIA GLGKAAELVT QNCEAYEAHM RDVRDYLEER LEAEFGQKRI HLNSQFPGTQ RLPNTCNFSI RGPRLQGHVV LAQCRVLMAS VGAACHSDHG DQPSPVLLSY GVPFDVARNA LRLSVGRSTT RAEVDLVVQD LKQAVAQLED QA (145-445 aa encoded by BC007891)
Target Information
The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSCL; mSCL; Selenocysteine lyase; selenocysteine lyase; Selenocysteine reductase; selenocysteine reductase; unnamed protein product
Gene Aliases: 9830169H08; A930015N15Rik; hSCL; SCL; SCLY; Scly1; Scly2
UniProt ID: (Human) Q96I15, (Mouse) Q9JLI6, (Rat) Q68FT9
Entrez Gene ID: (Human) 51540, (Mouse) 50880, (Rat) 363285
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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