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Alomone Labs, LTD
SCN4B (NaV beta 4) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
SCN4B (NaV beta 4) (extracellular) Antibody (ASC-044-200UL) in ICC/IF
Expression of NaV beta 4 in rat PC12 cells - Cell surface detection of NaV beta 4 in intact living ratpheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-SCN4B (NaV beta 4) (extracellular) Antibody (#ASC-044), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells.
Product Details
ASC-044-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85-98 of rat beta 4 subunit of voltage-gated Na+channels, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Amount
170 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sodium channel accessory subunit; sodium channel beta 4 subunit; Sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; sodium channel, voltage-gated, type IV, beta subunit; unnamed protein product; voltage gated sodium channel beta 4 subunit
Gene Aliases: ATFB17; Gm1471; LQT10; Navbeta4; SCN4B
UniProt ID: (Human) Q8IWT1, (Rat) Q7M730, (Mouse) Q7M729
Entrez Gene ID: (Human) 6330, (Rat) 315611, (Mouse) 399548
ion transport
sodium ion transport
positive regulation of sodium ion transport
neuronal action potential
sodium ion transmembrane transport
establishment of localization in cell
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
AV node cell action potential
regulation of heart rate by cardiac conduction
biological_process
regulation of ion transmembrane transport
AV node cell to bundle of His cell communication
regulation of sodium ion transmembrane transporter activity
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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