This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: ELLDEFAREN IDSLYNVNLS KGRAALSATV PRHEPPFHLD REIRLQRLSH SGSRVRVGFR LCNSTGGDCF YRGYTSGVAA VQDWYHFHYV DILALLPAAW EDSHGSQDGH FVLSCSYDGL DCQARQFRTF HHPTYGSCYT VDG
Highest antigen sequence identity to the following orthologs: Mouse - 26%, Rat - 25%.
SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amiloride-sensitive sodium channel subunit delta; Delta-ENaC; Delta-NaCH; Epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; sodium channel, non voltage gated 1 delta subunit; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, voltage-gated, type I, delta polypeptide
Gene Aliases: DNACH; ENaCd; ENaCdelta; SCNED; SCNN1D
UniProt ID: (Human) P51172
Entrez Gene ID: (Human) 6339