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Invitrogen
SCRIB Polyclonal Antibody
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FIGURE: 1 / 1
SCRIB Antibody (PA5-115873) in WB
Western blot analysis of SCRIB in extracts from various samples. Samples were incubated with SCRIB polyclonal antibody (Product # PA5-115873). Lane 1: Mcf7 cells (h2o2 treatment), blocked with antigen-specific peptides; Lane 2: Mcf7 cells (h2o2 treatment); Lane 3: Hela cells (heat-shock treatment); Lane 4: Rat brain; Lane 5: Mouse brain.
Product Details
PA5-115873
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SCRIB(Accession Q14160), corresponding to amino acid residues A1194-G1244.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Scribble.
Target Information
SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adaptor protein; circletail; hScrib; hSCRIB1-N1; PDZ-domain protein scribble; Protein LAP4; Protein scribble homolog; S Vartul; Scribble; scribble homolog 1; scribbled homolog; scribbled planar cell polarity protein
Gene Aliases: AI118201; Crc; CRIB; CRIB1; KIAA0147; LAP4; mKIAA0147; oSCRIB; RGD1565055; SCRB1; SCRIB; SCRIB1; VARTUL
UniProt ID: (Human) Q14160, (Mouse) Q80U72
Entrez Gene ID: (Human) 23513, (Mouse) 105782, (Rat) 362938
establishment of T cell polarity
neural tube closure
positive regulation of receptor recycling
auditory receptor cell morphogenesis
regulation of translation
protein localization
cell proliferation
epithelial structure maintenance
positive regulation of epithelial to mesenchymal transition
synaptic vesicle targeting
morphogenesis of embryonic epithelium
cell migration
cochlear nucleus development
establishment of cell polarity
cell differentiation
polarized epithelial cell differentiation
positive regulation of interferon-gamma production
establishment or maintenance of apical/basal cell polarity
establishment of apical/basal cell polarity
post-anal tail morphogenesis
wound healing
positive regulation of apoptotic process
receptor clustering
astrocyte cell migration
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of mitotic cell cycle
negative regulation of translational initiation
negative regulation of activated T cell proliferation
synaptic vesicle endocytosis
positive chemotaxis
auditory receptor cell stereocilium organization
inner ear receptor stereocilium organization
apoptotic process involved in morphogenesis
mammary gland duct morphogenesis
protein localization to adherens junction
activation of GTPase activity
cell-cell adhesion
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
regulation of postsynaptic neurotransmitter receptor internalization
multicellular organism development
asymmetric protein localization
single organismal cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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