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Invitrogen
SCRIB Polyclonal Antibody
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FIGURE: 1 / 3
SCRIB Antibody (PA5-66680) in ICC/IF
Immunofluorescence analysis of SCRIB was performed using MCF7 and Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SCRIB Polyclonal Antibody (Product # PA5-66680) at 1:200 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32731) at a dilution of 1:2... View More
Product Details
PA5-66680
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SCRIB. Recombinant protein control fragment (Product #RP-107328).
Conjugate
Form
Liquid
Concentration
0.40 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RLLEVNQQSLL GLTHGEAVQL LRSVGDTLTV LVCDGFEAST DAALEVSPGV IANPFAAGIG HRNSLESISS IDRE
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Target Information
SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adaptor protein; hScrib; hSCRIB1-N1; Protein LAP4; Protein scribble homolog; S Vartul; Scribble; scribbled homolog; scribbled planar cell polarity protein
Gene Aliases: CRIB1; KIAA0147; LAP4; oSCRIB; SCRB1; SCRIB; SCRIB1; VARTUL
UniProt ID: (Human) Q14160
Entrez Gene ID: (Human) 23513
establishment of T cell polarity
neural tube closure
positive regulation of receptor recycling
auditory receptor cell morphogenesis
regulation of translation
protein localization
cell proliferation
epithelial structure maintenance
positive regulation of epithelial to mesenchymal transition
synaptic vesicle targeting
morphogenesis of embryonic epithelium
cell migration
cochlear nucleus development
establishment of cell polarity
cell differentiation
polarized epithelial cell differentiation
positive regulation of interferon-gamma production
establishment or maintenance of apical/basal cell polarity
establishment of apical/basal cell polarity
post-anal tail morphogenesis
wound healing
positive regulation of apoptotic process
receptor clustering
astrocyte cell migration
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of mitotic cell cycle
negative regulation of translational initiation
negative regulation of activated T cell proliferation
synaptic vesicle endocytosis
positive chemotaxis
auditory receptor cell stereocilium organization
inner ear receptor stereocilium organization
apoptotic process involved in morphogenesis
mammary gland duct morphogenesis
protein localization to adherens junction
activation of GTPase activity
cell-cell adhesion
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
regulation of postsynaptic neurotransmitter receptor internalization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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