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Proteintech
SDHB Polyclonal Antibody
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Product Details
10620-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SDHB Fusion Protein Ag0968 (1-280 aa encoded by BC007840)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAVVALSL RRRLPATTLG GACLQASRGA QTAAATAPRI KKFAIYRWDP DKAGDKPHMQ TYEVDLNKCG PMVLDALIKI KNEVDSTLTF RRSCREGICG SCAMNINGGN TLACTRRIDT NLNKVSKIYP LPHMYVIKDL VPDLSNFYAQ YKSIEPYLKK KDESQEGKQQ YLQSIEEREK LDGLYECILC ACCSTSCPSY WWNGDKYLGP AVLMQAYRWM IDSRDDFTEE RLAKLQDPFS LYRCHTIMNC TRTCPKGLNP GKAIAEIKKM MATYKEKKAS V (1-280 aa encoded by BC007840)
Target Information
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ92337; Ip; iron-sulfur subunit; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit; OTTHUMP00000044624; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); succinate-ubiquinone oxidoreductase Ip subunit precursor; unnamed protein product
Gene Aliases: 0710008N11Rik; CWS2; IP; MC2DN4; PGL4; PPGL4; SDH; SDH1; SDH2; SDHB; SDHIP
UniProt ID: (Human) P21912, (Mouse) Q9CQA3, (Rat) P21913
Entrez Gene ID: (Human) 6390, (Mouse) 67680, (Rat) 298596
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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