Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
SDPR Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
12339-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SDPR Fusion Protein Ag2990 (73-426 aa encoded by BC016475)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal SDPR antibody raised against the C-terminus of human SDPR. SDRP of molecular masses 115 kDa and 100 kDa were found in neutrophils, monocytes, lymphocytes, platelets and erythrocytes. In platelets, however, the principal SDRP is a cytosolic protein of molecular mass 68 kDa.
Immunogen sequence: QENQHKMEQ RQISLEGSVK GIQNDLTKLS KYQASTSNTV SKLLEKSRKV SAHTRAVKER MDRQCAQVKR LENNHAQLLR RNHFKVLIFQ EENEIPASVF VKQPVSGAVE GKEELPDENK SLEETLHTVD LSSDDDLPHD EEALEDSAEE KVEESRAEKI KRSSLKKVDS LKKAFSRQNI EKKMNKLGTK IVSVERREKI KKSLTSNHQK ISSGKSSPFK VSPLTFGRKK VREGESHAEN ETKSEDLPSS EQMPNDQEEE SFAEGHSEAS LASALVEGEI AEEAAEKATS RGSNSGMDSN IDLTIVEDEE EESVALEQAQ KVRYEGSYAL TSEEAERSDG DPVQPAVLQV HQTS (73-426 aa encoded by BC016475)
Target Information
The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Caveolae-associated protein 2; cavin 2; Cavin-2; phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS-p68; SDPR; sdpr {ECO:0000312|EMBL:AAH81956.1}; serum deprivation response protein; Serum deprivation-response protein
Gene Aliases: cavin-2; CAVIN2; PS-p68; SDPR; SDR
UniProt ID: (Human) O95810, (Mouse) Q63918, (Rat) Q66H98
Entrez Gene ID: (Human) 8436, (Mouse) 20324, (Rat) 316384
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support