Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS
Predicted Reactivity: Xenopus laevis (81%), Chicken (90%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Semaphorin 3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (semaphorin) 3A; coll-1; COLL1; collapsin 1; collapsin-1; Hsema-I; Hsema-III; immunoglobulin domain (Ig); secreted; Sema D; sema domain; sema domain, immunoglobulin domain (Ig), short basic domain, sec; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Sema III; SEMA1; SEMAD; SEMAIII; SEMAL; Semaphorin 3a; semaphorin D; Semaphorin III; semaphorin L; Semaphorin-3A; Semaphorin-D; SemD; short basic domain
Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMA3A; SEMAD; SEMAIII; SEMAL; SemD