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The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved approximately 400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.
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Protein Aliases: M-sema H; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Sema H; Semaphorin-3E; Semaphorin-H
Gene Aliases: 6430702L12; AA408817; coll-5; KIAA0331; M-SEMAH; M-SemaK; mKIAA0331; SEMA3E; SEMAH; Semh
UniProt ID: (Human) O15041, (Mouse) P70275
Entrez Gene ID: (Human) 9723, (Mouse) 20349, (Rat) 296789
Molecular Function:
membrane-bound signaling molecule
intercellular signal molecule
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