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Product Details
PA5-104122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SEPT5(Accession Q99719), corresponding to amino acid residues R207-G257.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853450
Product Specific Information
Antibody detects endogenous levels of total SEPT5.
Target Information
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDCrel-1; cell division control related protein 1; Cell division control-related protein 1; peanut-like 1; peanut-like 1 homolog; Peanut-like protein 1; platelet glycoprotein Ib beta chain; Septin-5
Gene Aliases: 5-Sep; CDCREL; CDCREL-1; CDCrel-1A; CDCREL1; H5; HCDCREL-1; PNUTL1; SEPT5; SEPTIN5
UniProt ID: (Human) Q99719, (Mouse) Q9Z2Q6
Entrez Gene ID: (Human) 5413, (Mouse) 18951, (Rat) 116728
Performance Guarantee
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