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Abnova
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FIGURE: 1 / 1
Sequence of this protein is as follows: MVAQQKNLEG YVGFANLPNQ VYRKSVKRGF EFTLMVVGES GLGKSTLINS LFLTDLYSPE YPGPSHRIKK TVQVEQSKVL IKEGGVQLLL TIVDTPGFGD AVDNSNCWQP VIDYIDSKFE DYLNAESRVN RRQMPDNRVQ CCLYFIAPSG HGLKPLDIEF MKRLHEKVNI IPLIAKADTL TPEECQQFKK QIMKEIQEHK IKIYEFPETD DEEENKLVKK IKDRLPLAVV GSNTIIEVNG KRVRGRQYPW GVAEVENGEH CDFTILRNML IRTHMQDLKD VTNNVHYENY RSRKLAAVTY NGVDNNKNKG QLTKSPLAQM EEERREHVAK MKKMEMEMEQ VFEMKVKEKV QKLKDSEAEL QRRHEQMKKN LEAQHKELEE KRRQFEDEKA NWEAQQRILE QQNSSRTLEK NKKKGKIF
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
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